Mitochondrial-derived peptides
MOTS-c research peptide
MOTS-c is a 16-residue peptide encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene. First described in 2015, it is one of a small group of mitochondrial-derived peptides studied in cell and molecular biology.
For in-vitro laboratory research only. Not for human or veterinary use.
Specifications
- Compound
- MOTS-c
- Also known as
- Mitochondrial open reading frame of the 12S rRNA-c
- Class
- Mitochondrial-derived peptides
- Length
- 16 amino acids
- Sequence
MRWQEMGYIFYPRKLR- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Form
- Lyophilized powder, sealed vial
- Vial sizes
- 10mg
- Purity release standard
- ≥ 99.0% by HPLC-UV, identity by LC-MS
- Storage
- −20 °C, dry, protected from light
- PubChem
- CID 146675088
Lot release testing
Each MOTS-c lot is released only after it passes every assay below. Lots under 99.0% purity do not ship.
| Assay | Method | Release criterion |
|---|---|---|
| Purity | HPLC-UV | ≥ 99.0% |
| Net peptide content | Quantitative HPLC | ≥ 100% of label |
| Identity | LC-MS | Matches theoretical mass |
| Appearance | Visual | White lyophilized cake |
| Fentanyl screen | LC-MS/MS | Not detected |
| Heavy metals | ICP-MS | Within specification |
| Sterility | PCR | Not detected |
| Endotoxin | LAL | Within specification |
Frequently asked questions
What is MOTS-c?
MOTS-c is a 16-residue peptide encoded by a short open reading frame within the mitochondrial 12S ribosomal RNA gene. First described in 2015, it is one of a small group of mitochondrial-derived peptides studied in cell and molecular biology.
How is each MOTS-c lot tested?
Every lot is tested at an ISO/IEC 17025 accredited third-party laboratory against an eight-assay panel: HPLC-UV purity, quantitative net peptide content, LC-MS identity, appearance, a fentanyl screen, heavy metals by ICP-MS, sterility by PCR, and endotoxin by LAL. The certificate is published before the lot ships.
How do I verify the certificate for my MOTS-c vial?
Scan the QR code on the vial label to open the certificate for that exact lot, or search the lot number in the North Wall COA library.
Is MOTS-c for human use?
No. North Wall sells this compound solely for in-vitro laboratory research by qualified researchers aged 21 and over. It is not for human or veterinary use, and North Wall does not provide use, preparation, or dosing guidance.
Related reference pages
Molecular data: PubChem CID 146675088. Lot-specific values appear on the certificate for each batch.