Lab handling · 5 min read
Lyophilized Peptide Storage and Stability in the Laboratory
Storage temperatures, light and moisture control, and inventory practices that protect the stability of lyophilized research peptides.
Lyophilization (freeze-drying) removes water from a peptide solution under vacuum, leaving a dry cake or powder. Dry peptides are far more stable than peptides in solution, which is why research peptides ship lyophilized. Good storage keeps that stability intact for the life of the lot.
Temperature
For long-term storage, most lyophilized peptides are kept at −20 °C or colder. Short periods at room temperature, such as transit, are generally tolerated by the dry form, which is why cold-chain shipping is usually unnecessary. Avoid repeated warming and cooling of the same vial.
Moisture
Lyophilized peptides are often hygroscopic. Let a cold vial reach room temperature before opening it so that condensation does not form on the powder, and keep vials sealed. A desiccator is useful for opened stock.
Light and oxygen
Sequences containing tryptophan, methionine, or cysteine are more prone to oxidation. Keep vials in their packaging or in the dark, and minimize headspace exposure.
Inventory practices
- Log each vial by lot number on receipt
- Keep the matching certificate of analysis with lab records
- Use first-in, first-out rotation
- Record freezer temperature excursions
Each North Wall label carries a QR code linked to the lot certificate, which simplifies inventory records. Browse certificates.
Educational content for laboratory professionals. North Wall products are for in-vitro research only and are not for human or veterinary use.